The Organ Supply Gap Fails Critical Patient Needs
In 1954, the kidney was the first human organ to be transplanted. The liver, heart, and pancreas were successfully transplanted by the late 1960s.
Currently, the primary treatment option for patients with organ failure is an organ transplantation. Unfortunately, due to a shortage of transplantable organs, thousands of patients on the transplant wait list die each year.
The field of transplant desperately needs a new option.
Organ Crisis Quick Facts
The U.S. national transplant waiting list continues to grow, with a new patient added to the list every 10 minutes.
people in the US need a lifesaving organ transplant (total waiting list candidates). Of those, 75,865 people are on the active waiting list.
On average, just 92 transplants take place each day in the U.S., highlighting the gap between organ supply and demand.
Xenotransplantation, or the transplantation of organs, tissues and cells between different species, has the potential to address the current organ crisis, with the pig currently considered to be the best potential donor of biologic material for humans.
However, two key hurdles have prevented the advancement of porcine organ xenotransplantation to the clinic:
In 1997, concerns about the porcine endogenous retrovirus (PERV) and the potential for cross-species transmission to humans halted activity in the field.
Molecular incompatibilities between species drive acute and chronic rejection of the transplanted organ. With the advent of advances in gene editing technology, addressing these incompatibilities is now possible.
The eGenesis Solution
eGenesis is uniquely positioned to tackle the challenges that have impeded the field of xenotransplantation, develop safe and durable human compatible organs, and to ultimately address the global organ crisis.
Learn about our process for bringing human-compatible organs to patients in need.